At first look, I thought it was silly. But it has quickly grown on me. "It" is Visual Studio layout that is much easier on the eyes than the traditional high contrast. You can have a look here. (it's not the most attractive website, btw.) The group of us that are using it generally agree that there are necessary tweeks. Particularly, the highlight color doesn't do it for me (too hard to see), so I changed mine to match the background and font of the debugging windows, which are a fun green-screen kind of thing.
At the same time, my laptop is capable of 1920 x 1200 display. It looks great and every application is a vast ocean for editors and windows. but in my old age I find myself leaning forward to squint at text that is barely a millimeter tall. I have also found a "new to me" thing in Vista. Navigate to Control Panel\Appearance and Personalization\Personalization and choose Adjust font size (DPI). You can keep the high resolution, but it makes things much more readable. You are going to sacrifice some screen real estate, which isn't easy. Let go, man.